Visions and voices and fear and despair cannot be captured by CT scan or measured in the amplitude of EKG waves. Try as we might, we simply cannot predict which of our patients will kill themselves, which will murder their children, and which will leave the hospital healed, never to return.

I go dreaming into the future, where I see nothing, nothing. I have no plans, no idea, no project, and, what is worse, no ambition. Something – the eternal ‘what’s the use?’ – sets its bronze barrier across every avenue that I open up in the realm of hypothesis.

In one of his darker moments, the irony started him laughing and he couldn't stop, and the sounds that came from him, before finally tapering into sobs, were so far from mirth they might have been the forced inversion of laughter-like a soul pulled inside out to reveal its rawest meats.

And in despair I bowed my head;"There is no peace on earth," I said;"For hate is strong,And mocks the songOf peace on earth, good-will to men!"Then pealed the bells more loud and deep:"God is not dead, nor doth he sleep!The Wrong shall fail,the Right prevail,With peace on earth, good-will to men!

Of all my old associations, of all my old pursuits and hopes, of all the living and the dead world, this one poor soul alone comes natural to me, and I am fit for.  There is a tie of many suffering years between us two, and it is the only tie I ever had on earth that Chancery has not broken!

I have had to experience so much stupidity, so many vices, so much error, so much nausea, disillusionment and sorrow, just in order to become a child again and begin anew. I had to experience despair, I had to sink to the greatest mental depths, to thoughts of suicide, in order to experience grace.

You’ve had many ordeals in the past. During these ordeals, life seemed unbearable. You may have collapsed from the exhaustion of hopelessness and curled into a fetal position. Regardless of how difficult this new ordeal may be, as with the others, this too will be overcome. It will make you stronger.

Think it over carefully. This is very important," I say, "because to believe something, whatever it might be, is the doing of the mind. Do you follow? When you say you believe, you allow the possibility of disappointment. And from disappointment or betrayal, there may come despair. Such is the way of the mind.

He pried Clara's arms loose and stood up, smoothing his wrinkled coat. Clara looked straight into his face. Her eyelids were red, but her gaze was like a lance. Dr. Wintermute had a sudden, uncomfortable conviction that she had seen into his soul. It was a look he was to remember often in the weeks to come.

...stooping very low, He engraves with careHis Name, indelible, upon our dust;And from the ashes of our self-despair,Kindles a flame of hope and humble trust.He seeks no second site on which to build,But on the old foundation, stone by stone,Cementing sad experience with grace,Fashions a stronger temple of His own.

Day after day he roamed about in the arctic cold, his soul filled full of bitterness and despair. He saw the world of civilization then more plainly than ever he had seen it before; a world in which nothing counted but brutal might, an order devised by those who possessed it for the subjugation of those who did not.

Have you ever felt happy and miserable at the same time?” I sighed.“Yes.” Hutch sat up. He threw the covers back and got out of bed. He opened up the blinds sending rays of bright sunlight into his room. “But I got over it. I figured out no matter how much I worried about it nothing ever changed.

And maybe, although it was a thing you could hardly bear to think about, like death or your last judgment, maybe he would be the last one ever and he would walk away now and it would only be a question of waiting for it all to end and hoping for better things in the next world. But that was silly, it was never too late.

The air in my home is heavy with my mom's unhappiness. And her exhaustion. And her sheer dissatisfaction with her life. And I hate it. I can be up in my room when she's in the kitchen below and I feel her despair seeping up through the floorboards. You can hear her banging pots and pans or cursing the vacuum cleane

The death of a dream can in fact serve as the vehicle that endows it with new form, with reinvigorated substance, a fresh flow of ideas, and splendidly revitalized color. In short, the power of a certain kind of dream is such that death need not indicate finality at all but rather signify a metaphysical and metaphorical leap forward.