What does despair mean to someone who interprets that emotion as a chemical reaction in the brain?

When I think of all the harm [the Bible] has done, I despair of ever writing anything to equal it.

The difference between hope and despair is a different way of telling stories from the same facts.

What is unbelief but the despair, dictated by the dominant powers, that nothing can really change?

When you run out of hope, everything is backwards. Your heart wants the opposite of what it needs.

There is a dark place calling to me, but I will not go just yet. I know I can't return from it.

Discouragement is like a scorpion in your shoe; it takes courage to toss it out so you can move on.

There's no such thing as perfect writing, just like there's no such thing as perfect despair.

The artist's job is not to succumb to despair but to find an antidote for the emptiness of existence.

Don't degrade your soul to the extent of believing in curses. No man can curse you except your maker.

Is there any good news?' Tesla said.Who ever promised that? Who ever said there'd be good news?

As ofttimes as it rains on my little spot of earth, you'd think I'd grow accustomed to the gloom.

She (the First Lady, entering the room with her gravely wounded husband) would admit fear but not despair.

Losing your life is not the worst thing that can happen. The worst thing is to lose your reason for living.

Despair is the price one pays for self-awareness. Look deeply into life, and you'll always find despair.