Sometimes it all becomes too much. Your body and mind will just give way. Part of you may want to blissfully fade into nothing, but you never do. After a while all the memories and emotions make you shut down but never fully disappear—it’s safer for you this way, to be excluded. It’s a time to be alone, to heal, and to find yourself. It doesn’t mean you’ve given up or stopped trying; it just means you know what’s best for you.Breathing is medicine. I forgot how to breathe, but I’m learning all over again.

The situation with regard to insulin is particularly clear. In many parts of the world diabetic children still die from lack of this hormone. ... [T]hose of us who search for new biological facts and for new and better therapeutic weapons should appreciate that one of the central problems of the world is the more equitable distribution and use of the medical and nutritional advances which have already been established. The observations which I have recently made in parts of Africa and South America have brought this fact very forcible to my attention.

It has been demonstrated that a species of penicillium produces in culture a very powerful antibacterial substance which affects different bacteria in different degrees. Generally speaking it may be said that the least sensitive bacteria are the Gram-negative bacilli, and the most susceptible are the pyogenic cocci ... In addition to its possible use in the treatment of bacterial infections penicillin is certainly useful... for its power of inhibiting unwanted microbes in bacterial cultures so that penicillin insensitive bacteria can readily be isolated.

Medicine rests upon four pillars—philosophy, astronomy, alchemy, and ethics. The first pillar is the philosophical knowledge of earth and water; the second, astronomy, supplies its full understanding of that which is of fiery and airy nature; the third is an adequate explanation of the properties of all the four elements—that is to say, of the whole cosmos—and an introduction into the art of their transformations; and finally, the fourth shows the physician those virtues which must stay with him up until his death, and it should support and complete the three other pillars.

I had seen that once before, bleeding water. A little baby I worked on as a resident in training. That poor kid had been shot as well—his father had blasted away the top of his head with a shotgun—and we couldn't begin to stop the bloodletting in that case. "Looking pretty thin down here," I hollered when the stuff coming out his wounds was no more than pink salt water. That baby's heart stopped, started, stopped and started a dozen times before it finally gave up the ghost and we pronounced him. I could have read a newspaper through the watery stuff coming out his veins by then.

If you listen to your body and your intuition, they’ll guide you well. There are countless ways to develop listening skills. Some helpful and classic practices include: dancing and drumming, sitting and walking meditations, t’ai chi or chi kung, painting or journal writing. It’s important to find what works for you, and even the time of day or night that works best for you. Whatever you choose, the commonality is that they all offer an opportunity for quieting the mind, and slowing down enough to bepresent and able to listen for inner guidance—and guidance from the plants themselves.

The U.S. has a so-called health care system that has nothing to do with the promotion of health. Those who run this system do not care about your health, and it's far from being a system. It's a fragmented patchwork of procedure-oriented services that are meshed in a voluminous trail of paper payments, with little relevance to community-based needs. This misdirected, disease-managed non-care system of symptom suppression demands more and more treatment at higher and higher costs. If they cared at all, you'd be treated like a human, not like a number resembling, quite frankly, the ear tags on a cattle herd.

Betterment is perpetual labor. The world is chaotic, disorganized, and vexing, and medicine is nowhere spared that reality. To complicate matters, we in medicine are also only human ourselves. We are distractible, weak, and given to our own concerns. Yet still, to live as a doctor is to live so that one's life is bound up in others' and in science and in the messy, complicated connection between the two It is to live a life of responsibility. The question then, is not whether one accepts the responsibility. Just by doing this work, one has. The question is, having accepted the responsibility, how one does such work well.

The core predicament of medicine - the thing that makes being a patient so wrenching, being a doctor so difficult, and being a part of society that pays the bills they run up so vexing - is uncertainty. With all that we know nowadays about people and diseases and how to diagnose and treat them, it can be hard to see this, hard to grasp how deeply uncertainty runs. As a doctor, you come to find, however, that the struggle in caring for people is more often with what you do not know than what you do. Medicine's ground state is uncertainty. And wisdom - for both the patients and doctors - is defined by how one copes with it.

I love the imagery of struggle. I sometimes wish I were suffering in a good cause, or risking my life for the good of others, instead of just being a gravely endangered patient. Allow me to inform you, though, that when you sit in a room with a set of other finalists, and kindly people bring a huge transparent bag of poison and plug it into your arm, and you either read or don't read a book while the venom sack gradually empties itself into your system, the image of the ardent solider is the very last one that will occur to you. You feel swamped with passivity and impotence: dissolving in powerlessness like a sugar lump in water.

I would not be among you to-night (being awarded the 1964 Nobel Prize in Physiology or Medicine) but for the mentors, colleagues and students who have guided and aided me throughout my scientific life. I wish I could name them all and tell you their contributions. More, however, than anyone else it was the late Rudolf Schoenheimer, a brilliant scholar and a man of infectious enthusiasm, who introduced me to the wonders of Biochemistry. Ever since, I have been happy to have chosen science as my career, and, to borrow a phrase of Jacques Barzun, have felt that 'Science is, in the best and strictest sense, glorious entertainment'.

We even save a few lives, but only a fraction of the lives that need to be saved. Soon, we will leave and when we leave there will be nothing to take our place. The meningitis epidemic, cholera, measles, typhoid fever, all preventable diseases, will return and continue as before. The only solution is a political solution, national public health programs, responsible corporations who reap only as much as they sow. Shell Oil with a conscience. Nigeria doesn't need us. What we do here is less than nothing. We take the pressure off the powers that be, making it easier for those who plunder to keep on plundering. This is the humanitarian aid paradox.

En el folclore de la ciencia hay una historia muchas veces contada sobre el momento del descubrimiento: la aceleración del pulso, la luminosidad espectral que adquieren hechos comunes y corrientes, el segundo de parálisis y arrebato en que las observaciones cristalizan y encajan en patrones, como piezas de un caleidoscopio. La manzana cae del árbol. El hombre sale de un salto de la bañera. La escurridiza ecuación cuadra. Pero hay otro momento de descubrimiento -su antítesis- que se menciona contadas veces: el descubrimiento de un fracaso. Es un momento, que por lo común, el científico conoce en soledad.

Burnout at its deepest level is not the result of some train wreck of examinations, long call shifts, or poor clinical evaluations. It is the sum total of hundreds and thousands of tiny betrayals of purpose, each one so minute that it hardly attracts notice. When a great ship steams across the ocean, even tiny ripples can accumulate over time, precipitating a dramatic shift in course. There are many Tertius Lydgates, male and female, inhabiting the lecture halls, laboratories, and clinics of today’s medical schools. Like latter-day Lydgates, many of them eventually find themselves expressing amazement and disgust at how far they have veered from their primary purpose.

Swords, Lances, arrows, machine guns, and even high explosives have had far less power over the fates of nations than the typhus louse, the plague flea, and the yellow-fever mosquito. Civilizations have retreated from the plasmodium of malaria, and armies have crumbled into rabbles under the onslaught of cholera spirilla, or of dysentery and typhoid bacilli. Huge areas have bee devastated by the trypanosome that travels on the wings of the tsetse fly, and generations have been harassed by the syphilis of a courtier. War and conquest and that herd existence which is an accompaniment of what we call civilization have merely set the stage for these more powerful agents of human tragedy.