I am a brain, Watson. The rest of me is a mere appendix.

It is fortunate for this community that I am not a criminal.

It's quite exciting," said Sherlock Holmes, with a yawn.

I am lost without my Boswell.[Sherlock Holmes on Dr. Watson.]

My mind rebels at stagnation, give me problems, give me work!

My horror at his crimes was lost in my admiration at his skill.

I wanted to end the world, but I'll settle for ending yours.

I am the most incurably lazy devil that ever stood in shoe leather.

You know my method. It is founded upon the observation of trifles.

My business is that of every other good citizen - to uphold the law.

...So you can put that in your pipe and smoke it Mr. Busybody Holmes.

What is out of the common is usually a guide rather than a hindrance.

Moriarty: . . .everything I have to say has already crossed your mind.

You know, I never did call him Watson – he was John, simply John.

I fear that if the matter is beyond humanity, it is certainly beyond me.